Como proveedor líder de 1-Bromohexadecano, entregamos productos de alta calidad en diversos grados para satisfacer las necesidades cambiantes, empoderando a los clientes globales con soluciones químicas seguras, eficientes y conformes.
What are the main uses of Bromohexadecane?
1-Bromohexadecano, también conocido como bromuro de cetilo, es una materia prima crucial en el campo de la síntesis orgánica. Tiene una amplia gama de usos, cubriendo principalmente los siguientes fines:
Primero, en la preparación de tensioactivos, el 1-bromohexadecano juega un papel clave. Al reaccionar con los reactivos correspondientes, se pueden preparar tensioactivos catiónicos como el cetyltrimethylammonium bromuro. Dichos tensioactivos tienen excelentes propiedades de emulsión, dispersión y antiestática, y son ampliamente utilizados en productos químicos diarios, textiles, petróleo y otras industrias. Por ejemplo, en formulaciones de champú, puede mejorar el poder de descontaminación y la estabilidad de la espuma; en procesos de impresión y teñido de textiles, puede ayudar a que los tintes se dispersen uniformemente y mejoren la calidad del teñido.
Segundo, en el campo de la síntesis de medicamentos, el 1-bromohexadecano también tiene un valor importante. Como intermedio, participa en la construcción de muchas moléculas de medicamentos. La síntesis de algunos compuestos farmacológicamente activos específicos requiere la introducción de grupos alquilo de cadena larga con la ayuda del 1-bromohexadecano para optimizar la solubilidad lipídica de los medicamentos, mejorar su capacidad de transporte transmembrana y luego mejorar la biodisponibilidad. Por ejemplo, en algunos medicamentos para el tratamiento de enfermedades cardiovasculares, la estructura de cadena larga de carbono ayuda al medicamento a unirse a objetivos específicos y mejorar la eficacia.
Tercero, en el campo de la ciencia de materiales, el 1-bromohexadecano se usa a menudo para preparar materiales funcionales. Por ejemplo, en la preparación de materiales optoelectrónicos orgánicos, la introducción de su estructura de cadena larga de carbono puede ajustar la disposición y el modo de apilamiento de las moléculas del material, y mejorar las propiedades eléctricas y ópticas de los materiales autoensamblados, 1-bromohexadecano puede usarse como un bloque de construcción para formar una estructura supramolecular ordenada a través de interacciones intermoleculares, que se utiliza en sensores, portadores catalíticos y otros campos.
Cuarto, en reacciones de síntesis orgánica, 1-bromohexadecano se usa como reactivo de alquilación. Puede introducir hexadecillo en otras moléculas de compuestos orgánicos para lograr el crecimiento de la cadena de carbono y la modificación estructural. Por ejemplo, en reacciones de alquilación de Fu-gram, los aromáticos pueden alquilarse para generar compuestos aromáticos con estructuras específicas, expandiendo más caminos para la síntesis orgánica y enriqueciendo la variedad de compuestos orgánicos.
What are the physical properties of Bromohexadecane?
1-Bromohexadecane is also an organic compound. It has various physical properties and is quite useful in chemical engineering.
First of all, 1-bromohexadecane is often a colorless to light yellow oily liquid. Looking at it, it is clear and shiny, and exists stably at room temperature and pressure.
On its melting and boiling point, the melting point is about 17-19 ° C, and the boiling point is 336-337 ° C. This boiling point characteristic makes its state variable in a specific temperature range. When the temperature is lower than the melting point, it will solidify into a solid state; if it is higher than the boiling point, it will turn into a gaseous state.
Its density is about 0.999g/cm ³, which is heavier than water. When placed in water, it will sink to the bottom of the water. And insoluble in water, but soluble in many organic solvents, such as ethanol, ether, acetone, etc. This solubility is crucial in organic synthesis, extraction and other processes.
1-bromohexadecane has very low vapor pressure and weak volatility. This property makes it difficult to volatilize into the air at room temperature, reducing losses, and making it safer for storage and use.
In addition, its refractive index is about 1.458-1.460, and specific refraction phenomena will occur when light passes through. This optical property may be available in the fields of optical materials, analysis and testing, etc.
In summary, 1-bromohexadecane, with its unique physical properties, is of great value in many fields such as chemical industry, materials, scientific research, and is also a key substance in many processes and research.
1-Is Bromohexadecane chemically stable?
1 - Bromohexadecane is an organic compound. The stability of its chemical properties needs to be carefully observed.
In this compound, the bromine atom is connected to the hexadecane group. From a structural point of view, the hexadecane group is a long-chain alkyl group with a certain steric resistance. Although the bromine atom has a certain activity, its reactivity also changes due to the influence of the long-chain alkyl group.
Under normal temperature and pressure, 1 - Bromohexadecane is quite stable. Its intermolecular force is mainly van der Waals force. Due to the existence of long-chain alkyl groups, the intermolecular force is strong, resulting in a higher melting point and a relatively stable physical state.
Its stability will also change under specific conditions. In case of nucleophilic reagents, bromine atoms are easily replaced. Because bromine atoms have certain electronegativity, their carbon-bromine bonds are polar, and carbon atoms are partially positively charged, making them vulnerable to nucleophilic reagents and nucleophilic substitution reactions.
In addition, under high temperature or light conditions, carbon-bromine bonds can be homogenized and free radicals can be generated, which in turn triggers a series of free radical reactions. At this time, its stability is destroyed.
In general, 1-Bromohexadecane is chemically stable under normal conditions, but in case of special reagents or conditions, its stability will change and show different chemical activities.
What are the applications of bromohexadecane in synthesis?
1-Bromohexadecane is widely used in the field of synthesis. It can be used to prepare surfactants. Guanfu's ancient books, the preparation of surfactants, related to people's livelihood, such as daily cleaning products, such as soaps, lotions, etc., 1-bromohexadecane is often the key raw material. Based on it, through various reactions, it can become a surfactant with excellent emulsifying, dispersing, solubilizing and other properties, so that oil stains can be dissolved, stains can be easily removed, and it is beneficial to cleaning work.
Furthermore, in the process of organic synthesis, 1-bromohexadecane is also an important intermediate. It can be combined with many nucleophiles by nucleophilic substitution reaction. If it interacts with alcohols, it can produce ether compounds. Ethers are useful in chemical production, drug synthesis and other fields. In drug synthesis, ethers with specific structures may have unique pharmacological activities, which contribute to the creation of new drugs.
In the field of materials science, 1-bromohexadecane also plays a role. It can participate in the preparation of special functional materials, such as the modification of some polymer materials. With its long-chain alkyl structure, the introduction of polymer systems may improve the hydrophobicity and flexibility of materials, so that materials can exhibit better properties in waterproof, packaging, etc., and are suitable for different scenarios.
It can be seen that 1-bromohexadecane plays an indispensable role in the synthesis of many substances and the improvement of properties, just like masonry in Guangsha. It is of great value in various industries such as chemical, pharmaceutical, and materials.
What are the production methods of Bromohexadecane?
1-Bromohexadecane, also known as cetyl bromine, is a white to light yellow crystalline solid and is widely used in the field of organic synthesis. The common methods for its preparation are as follows:
First, hexadecanol and hydrobromic acid are used as raw materials and synthesized by acid catalysis. In this process, the hydroxyl group of hexadecanol reacts with the bromine ion of hydrobromic acid. After the following steps: first put the hexadecanol into the reaction vessel, then slowly add hydrobromic acid, and add an appropriate amount of sulfuric acid as a catalyst. The reaction needs to be refluxed at a certain temperature for several hours, during which the reaction process should be closely monitored. After the reaction is completed, the organic phase is separated by means of liquid separation, and then washed with sodium bicarbonate solution to remove the unreacted acid. Finally, the pure 1-bromohexadecane can be obtained by drying and distillation of anhydrous sodium sulfate. The raw materials of this method are easy to obtain, and the operation is not complicated. However, there are many by-products of the reaction, and the purity of the product may be affected.
Second, cetyl alcohol and phosphorus tribromide are prepared as raw materials. The reaction of cetyl alcohol and phosphorus tribromide is also a substitution reaction, and it is more efficient. During the specific operation, the cetyl alcohol is dissolved in a suitable organic solvent, such as ether or dichloromethane, and phosphorus tribromide is added dropwise at low temperature. The reaction is mild and After the reaction is completed, the product can be obtained by hydrolysis, extraction, drying and distillation. The product of this method has high purity, but phosphorus tribromide is highly corrosive, so special attention should be paid to safety during operation.
Third, cetane and bromine are used as raw materials, and prepared by free radical substitution reaction under the action of light or initiator. The cetane and bromine are mixed in a certain proportion, and an appropriate amount of initiator such as benzoyl peroxide is added to react under light conditions. During the reaction, bromine free radicals capture hydrogen atoms in the cetane molecule to generate 1-bromohexadecane. After the reaction, the product is purified by alkali washing, water washing, drying and vacuum distillation. The raw material cost of this method is low, but the reaction selectivity is poor, resulting in a variety of brominated products, which is cumbersome to separate and purify.
